Based on published research from Cell Reports Medicine (2022), Nature Metabolism (2019), and EPFL Switzerland
🔬 12% Muscle Strength Support — Backed by Research
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🔬 PEER-REVIEWED RESEARCH
Clinical Trial Shows 12% Muscle Strength Support
How 500mg of Urolithin A has been shown to support muscle strength and cellular health in adults 40-64
~ 4 min read
📊
~12%
Strength Support*
🔬
4
Month Trial
✅
40-64
Age Group Studied
📝
Peer
Reviewed Journal
*Based on Singh et al., Cell Reports Medicine, 2022. Individual results may vary.
After 40, Cellular Efficiency Naturally Declines
Research shows that mitochondrial function — the energy production system inside your cells — becomes less efficient with age. This may contribute to changes in strength and energy levels. Adults 40-64 are in a window where supporting cellular health may make a meaningful difference.
"For the first time, we have a compound that supports muscle strengthening at the cellular level — and it's been tested in a rigorous clinical trial."
1 Mitochondria: The Power Source Behind Your Muscles
Every muscle cell contains hundreds of mitochondria — cellular structures that produce the energy your muscles need to function. Think of them as tiny power plants.
The challenge: Research shows mitochondrial efficiency naturally declines with age. By your 40s and 50s, this decline becomes measurable — which may contribute to changes in how strong and energetic you feel.
After 40
Mitochondrial Efficiency Begins to Decline
Supporting cellular health becomes increasingly important
2 Mitophagy: Your Body's Cellular Quality Control
Your body has a natural process called mitophagy that helps clear out and recycle cellular components that are no longer functioning optimally. Think of it as quality control for your cells.
The issue: Research suggests this process becomes less efficient with age. Supporting mitophagy is an area of growing scientific interest for healthy aging.
Aging Cellular Components
Cells identify components that need attention
Mitophagy Supported
Urolithin A supports this natural process
Cellular Quality Maintained
Supporting healthy cellular function
3 Urolithin A: Supporting Cellular Health From Within
After years of research, scientists identified Urolithin A as a compound that supports the body's natural mitophagy process. It's been the subject of multiple clinical studies.
The challenge: Only an estimated 30-40% of people can produce meaningful amounts of Urolithin A naturally from food, depending on their gut bacteria. And you'd need to consume large quantities of pomegranates daily to approach the clinical dose.
500mg
The Clinical Research Dose
Per serving of Norena™ MITO+ Gummies
4 The Clinical Evidence
A randomized, placebo-controlled trial published in Cell Reports Medicine (2022) tested Urolithin A in adults ages 40-64 over 4 months.
Participants maintained their existing diet and exercise habits during the study — the only variable was the supplement.
Urolithin A Group
✅
~12% muscle strength improvement
✅
Improved mitochondrial biomarkers
✅
Safe and well-tolerated
Placebo Group
❌
No significant change
❌
No biomarker improvement
Individual results may vary. Based on Singh et al., Cell Reports Medicine, 2022.
5 Who May Want to Consider This?
The clinical trial studied adults ages 40-64 who maintained their existing lifestyle habits.
You may want to consider Urolithin A if you:
- Are between 40-64 years old
- Have noticed changes in your strength or energy
- Spend significant time sitting (desk work, driving)
- Want to support your muscle health as you age
- Are looking for research-backed cellular support
Important note: Urolithin A is not a replacement for exercise. Physical activity provides cardiovascular, bone density, mental health, and other benefits that supplements cannot replicate. This supports your cellular health as a complement to a healthy lifestyle.
Norena™ MITO+ Gummies
500mg Urolithin A Per Serving — The Clinical Research Dose
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Common Questions
How is this different from pomegranate juice?
Pomegranate contains precursors that may convert to Urolithin A — but only if you have specific gut bacteria, which research suggests only 30-40% of people do. Norena™ MITO+ delivers purified Urolithin A directly, regardless of your microbiome composition — at the dose used in clinical research.
How long until I may notice a difference?
The clinical trial measured outcomes at 4 months. Individual experiences vary. Some people report noticing changes in energy within a few weeks, while measurable strength changes typically require longer-term use. We recommend trying it for at least 90 days. Individual results may vary.
Does this replace exercise?
No. Exercise provides cardiovascular, bone density, mental health, and other benefits that no supplement can replace. Urolithin A supports cellular health and may complement an active lifestyle. In the clinical trial, participants maintained their existing activity levels — so it's designed to work alongside, not instead of, healthy habits.
Is this safe?
Urolithin A has received FDA GRAS (Generally Recognized As Safe) status and showed no serious adverse effects in clinical trials. However, as with any supplement, consult your physician before starting — especially if you take prescription medications.
What's your guarantee?
30-Day Money-Back Guarantee. If you're not satisfied within the first month, contact us for a full refund — no questions asked. Individual results may vary.
📚 Published Research References
- Singh A, D'Amico D, Andreux PA, et al. "Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults." Cell Reports Medicine. 2022;3(5):100633.
- Liu S, D'Amico D, Shankland E, et al. "Effect of Urolithin A Supplementation on Muscle Endurance and Mitochondrial Health in Older Adults." JAMA Network Open. 2022;5(1):e2144279.
- Andreux PA, et al. "The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans." Nature Metabolism. 2019;1:595-603.